Proanthocyanidins
What do they do? Proanthocyanidins—also called “OPCs” for oligomeric proanthocyanidins—are a class of nutrients belonging to the flavonoid family. Two of the main functions of proanthocyanidins are as antioxidants and in the stabilization of collagen and maintenance of elastin—two critical proteins in connective tissue, blood vessels, and muscle.1 2
Where are they found? Proanthocyanidins can be found in many plants, most notably pine bark and grape seeds, and skin. However, bilberry, cranberry, blackcurrant, green tea, black tea, and other plants also contain this flavonoid. Nutritional supplements containing extracts of proanthocyanidins from various plant sources are available, alone or in combination with other nutrients, in herbal extracts, capsules, and tablets.
In what conditions might proanthocyanidins be supportive?
• chronic venous insufficiency
Who is likely to be deficient? Flavonoids and proanthocyanidins are not classified as essential nutrients, since their absence does not induce a deficiency state. However, proanthocyanidins may have many health benefits, and anyone not eating a wide variety of plants will not derive these benefits.
How much should I take? Flavonoids (including proanthocyanidins and others) are a significant source of antioxidants in the average diet. Proanthocyanidins at 50-100 mg per day may be a reasonable supplemental level.
Are there any side effects or interactions? Flavonoids, in general, and proanthocyanidins, specifically, are free of side effects. Since they are water-soluble nutrients, excess intake is simply excreted in the urine.
Proanthocyanidins as antioxidants may have a sparing effect on the body’s stores of vitamin C.
References:
1. Mitcheva M, et al. Biochemical and morphological studies on the
effects of anthocyans and vitamin E on carbon tetrachloride induced liver injury. Cell
Mol Bio 1993;39(4):443-8.
2. Maffei F. et al. Free radical scavenging action and anti-enzyme activities of
procyanidines from Vitis vinifera. A mechanism for their capillary protective
action. Arzn Forsch 1994;44:592-601
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Copyright © 1998 Virtual Health, LLC
It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally-oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.The information presented in HealthNotes Online is for informational purposes only.