Fibrocystic Breast Disease Fibrocystic breast disease is a term colloquially given to a group of benign conditions affecting the breast. It is a very common benign condition in younger women. Both breasts become tender or painful and lumpy, and the symptoms vary at different times of the menstrual cycle.
Dietary changes that may be helpful:Total caffeine elimination reduces symptoms of fibrocystic disease.1 2 Caffeine is found in coffee, black and green tea, cola drinks, chocolate, and a number of over-the-counter drugs. The decrease in breast tenderness can take 6 months or more to occur after caffeine is eliminated. Breast lumpiness may not go away, but the pain often decreases.
Many doctors misunderstand the effect of caffeine. When researchers tell women to cut back or to eliminate caffeine for less than six months, the results are unimpressive.3 4 Moreover, some doctors are under the impression that fibrocystic women do not drink much coffee. However, for every study that says fibrocystic disease patients do not drink more coffee than other women,5 6 there is a study which says otherwise.7 8
More important, the original research did not claim that fibrocystic patients drink much coffeeonly that they are especially sensitive to it.
Twins with similar or identical genes should be affected the same by caffeine. For example, if one twin has fibrocystic symptoms and the other does not, the twin with symptoms will most likely be the coffee drinker, researchers have found.9
Fibrocystic disease has been linked to excess estrogen. When those with fibrocystic disease are put on a low-fat diet, their estrogen levels decrease.10 11 After three to six months, the pain and lumpiness also decrease.12 13 The link between fat and symptoms appears to be most strongly related to saturated fat.14 Foods high in saturated fat include meat and dairy products. Fish, nonfat dairy, and tofu are possible replacements.
Lifestyle changes that may be helpful: Exercise may decrease breast tenderness. In one study, women who ran 45 miles per menstrual cycle reported less breast tenderness as well as improvement in other symptoms, such as anxiety.15
Nutritional supplements that may be helpful: Several studies report that 200-600 IU of vitamin E per day, taken for several months, may reduce symptoms.16 17 Most double-blind research has not found vitamin E to relieve fibrocystic breast disease symptoms.18 19 Nonetheless, many women take 400 IU of vitamin E for three months to see if it helps.
As with vitamin E, the effectiveness of vitamin B6 remains unclear. Some,20 but not all,21 studies find that it reduces symptoms. Those with premenstrual syndrome in addition to breast tenderness should discuss the use of vitamin B6 with their nutritionally oriented doctor.
Some doctors of natural medicine use iodine for fibrocystic symptoms. In animals, iodine deficiency can cause the equivalent of fibrocystic disease.22 What appears to be the most effective formdiatomic iodine23is not readily available. Because some people are sensitive to iodine and high doses can alter thyroid function, it should not be taken without a doctors involvement.
Research suggests that evening primrose oil, or EPO, may reduce symptoms of fibrocystic disease.24 25 Many women take 3 grams per day of EPO for the alleviation of fibrocystic breast disease. It may take up to six months for optimal results.26
Are there any side effects or interactions? (Refer to the individual supplement for complete information.) Although side effects from vitamin B6 supplements are rare, at very high levels this vitamin can damage sensory nerves, leading to numbness in the hands and feet as well as difficulty walking. Vitamin B6 supplementation should be stopped if these symptoms develop. Pregnant and lactating women should not take more than 100 mg of vitamin B6. For other adults, vitamin B6 is usually safe in amounts of 200-500 mg per day,27 although occasional problems have been reported in this range.28 Side effects from vitamin B6 become more common when intake exceeds 2,000 mg per day; consequently, this supplement level should be avoided.29
High doses (several milligrams per day) of iodine can interfere with normal thyroid function and should not be taken without consulting a nutritionally oriented doctor.
Herbs that may be helpful: Since many women with fibrocystic breast disease and cyclical breast tenderness also suffer from premenstrual syndrome, or PMS, there is often an overlap in herbal recommendations.
Vitex has been shown to help re-establish normal balance of estrogen and progesterone during a womans menstrual cycle. This is important because some women will suffer from PMS and other menstrual irregularities due to underproduction of the hormone progesterone during the second half of their cycle. Vitex stimulates the pituitary gland to produce more luteinizing hormone, and this leads to a greater production of progesterone.30 Studies have shown that using vitex once in the morning over a period of several months will help normalize hormone balance and alleviate the symptoms of PMS.31
Use 40 drops of a liquid, concentrated vitex extract or one capsule of the equivalent dried, powdered extract once per day in the morning with some liquid. Vitex should be taken for at least four cycles to determine efficacy. Vitex should not be taken during pregnancy or with hormone therapy.
In traditional Chinese medicine, Dong quai, or Angelica sinensis, is often referred to as the female ginseng. Dong quai helps promote normal hormone balance and is particularly useful for women experiencing premenstrual cramping and pain.32 Many women take 2-3 grams of dong quai capsules or tablets per day.
Are there any side effects or interactions? (Refer to the individual herb for complete information.) Minor gastrointestinal upset and a mild skin rash with itching has been reported in less than 2% of the women monitored while taking vitex. Vitex is not recommended for use during pregnancy. It should not be taken together with hormone therapy.
Dong quai may cause some fair-skinned persons to become more sensitive to sunlight. Persons using it on a regular basis should limit prolonged exposure to the sun or other sources of ultraviolet radiation. Dong quai is not recommended for pregnant or lactating women.
Checklist for Fibrocystic Breast Disease
Nutritional Supplements
Herbs
Homeopathic Remedies
Vitamin E Vitex No homeopathy commonly used for this condition References:
1. Minton JP, Foecking MK, Webster DJT, Matthew RH. Caffeine, cyclic nucleotides, and breast disease. Surgery 1979;86:105-8.
2. Minton JP, Abou-Issa H, Reiches N, et al. Clinical and biochemical studies on methylxanthine-related fibrocystic breast disease. Surgery 1981;90:299-304.
3. Ernster VL, Mason L, Goodson WH, et al. Effects of a caffeine-free diet on benign breast disease: a randomized trial. Surgery 1982;91:263.
4. Allen S, Froberg DG. The effect of decreased caffeine consumption on benign proliferative breast disease: a randomized clinical trial. Surgery 1987;101:720-30.
5. Marshall JM, Graham S, Swanson M. Caffeine consumption and benign breast disease: a case-control comparison. Am J Publ Health 1982;72(6):610-2.
6. Lubin F, Ron E, Wax Y, et al. A case-control study of caffeine and methylxanthines in benign breast disease. JAMA 1985;253(16):2388-92.
7. Boyle CA, Berkowitz GS, LiVoisi VA, et al. Caffeine consumption and fibrocystic breast disease: a case-control epidemiologic study. J Natl Cancer Inst 1984;72:1015-9.
8. Vecchia C, Franceschi S, Parazzini F, et al. Benign breast disease and consumption of beverages containing methylxanthines. J Natl Cancer Inst 1985;74:995-1000.
9. Odenheimer DJ, Zunzunegui MV, King MC, et al. Risk factors for benign breast disease: A case-control study of discordant twins. AmJ Epidemiol 1984;120:565-71.
10. Rose DP, Boyar AP, Cohen C, Strong LE. Effect of a low-fat diet on hormone levels in women with cystic breast disease. I. Serum steroids and gonadotropins. J Natl Cancer Inst 1987;78:623-6.
11. Woods MN, Gorbach S, Longcope C, et al. Low-fat, high-fiber diet and serum estrone sulfate in premenopausal women. Am J Clin Nutr 1989;49:1179-83.References (continued):
12. Rose DP, Boyar A, Haley N, et al. Low fat diet in fibrocystic disease of the breast with cyclic mastalgia: a feasibility study. Am J Clin Nutr 1985;41(4):856 (abstract).
13. Boyd NF, McGuire V, Shannon P, et al. Effect of a low-fat high-carbohydrate diet on symptoms of cyclical mastopathy. Lancet 1988;ii:128-32.
14. Lubin F, Wax Y, Ron E, et al. Nutritional factors associated with benign breast disease etiology: a case-control study. Am J Clin Nutr 1989;50:551-6.
15. Prior JC, Vigna Y, Sciarretta D, et al. Conditioning exercise decreases premenstrual symptoms: a prospective, controlled 6-month trial. Fertil Steril 1987;47(3):402-8.
16. Abrams AA. Use of vitamin E in chronic cystic mastitis. N Engl J Med 1965;272(20):1080-1.
17. London RS, Sundaram GS, Schultz M, et al. Endocrine parameters and alpha-tocopherol therapy of patients with mammary dysplasia. Cancer Res 1981;41:3811-3.
18. Ernster VL, Goodson WH, Hunt TK, et al. Vitamin E and benign breast disease: a double-blind, randomized clinical trial. Surgery 1985;97:490-4.
19. London RS, Sundaram GS, Murphy L, et al. The effect of vitamin E on mammary dysplasia: a double-blind study. Obstet Gynecol 1985;65:104-6.
20. Brush MG, Perry M. Pyridoxine and the premenstrual syndrome. Lancet 1985;i:1399.
21. Smallwood J, Ah-Kye D, Taylor I. Vitamin B6 in the treatment of pre-menstrual mastalgia. Brit J Clin Pract 1986;40:532-3.References (continued):
22. Krouse TB, Eskin BA, Mobini J. Age-related changes resembling fibrocystic disease in iodine-blocked rat breasts. Arch Pathol Lab Med 1979;103:631-4.
23. Ghent WR, Eskin BA, Low DA, Hill L. Iodine replacement in fibrocystic disease of the breast. Canadian J Surg 1993;36:453-60.
24. Gateley CA, Miers M, Mansel RE, Hughes LE. Drug treatments for mastalgia: 17 years experience in the Cardiff mastalgia clinic. J Royal Soc Med 1992;85:12-5.
25. Mansel RE, Pye JK, Hughes LE. Effects of Essential fatty acids on cyclical mastalgia and noncyclical breast disorders. in Omega-6 essential fatty acids: Pathophysiology and roles in clinical medicine, Alan R Liss, New York, 1990,557-66.
26. Preece PE, Hanslip JI, Gilbert L, et al. Evening primrose oil (EFAMOL) for mastalgia. In: Clinical Uses of Essential Fatty Acids, ed. DF Horrobin, Montreal: Eden Press, 1982;147-54.
27. Gaby AR. Literature review & commentary. Townsend Letter for Doctors June 1990;338-9.
28. Parry G, Bredesen DE. Sensory neuropath with low-dose pyridoxine. Neurol 1985;35:1466-8.
29. Schaumburg H, Kaplan J, Windebank A, et al. Sensory neuropathy from pyridoxine abuse. N Engl J Med 1983;309(8):445-8.
30. Böhnert KJ, Hahn G. Phytotherapy in gynecology and obstetricsVitex agnus castus. Erfahrungsheilkunde 1990; 39:494-502.
31. Dittmar FW, Böhnert KJ, et al. Pre-menstrual syndrome: Treatment with a phytopharmaceutical. Therapiwoche Gynäkol 1992; 5:60-68.
32. Qi-bing M, Jing-yi T, Bo C. Advance in the pharmacological studies of radix Angelica sisnensis (oliv) diels (Chinese danggui). Chin Med J 1991; 104:776-81.
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It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally-oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.The information presented in HealthNotes Online is for informational purposes only.